Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Neutrophils are the primary cells recruited to inflamed sites during an innate immune
response to tissue damage and/or infection. They are finely sensitive to inciting stimuli to …

Neutrophils represent the first line of cellular defense against invading microorganism by
rapidly moving across the blood–endothelial cell (EC) barrier and exerting effector cell …

Stimuli that promote cell migration, such as chemokines, cytokines, and growth factors in
metazoans and cyclic AMP in Dictyostelium, activate signaling pathways that control …

Here we focus on how neutrophils have a key regulatory role in vascular inflammation.
Recent studies using advanced imaging techniques have yielded new insights into the …

Barrier structures (for example, epithelia around tissues and plasma membranes around
cells) are required for internal homeostasis and protection from pathogens. Wound detection …

Immunosenescence is the functional deterioration of the immune system during natural
aging. Despite increased susceptibility to bacterial infections in older adults, age-associated …