Colorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the
fourth most frequent cause of death having an oncological origin. It has been found that …

Colorectal cancer (CRC) is a major cause of cancer mortality worldwide, however, the
molecular mechanisms underlying the pathogenesis of CRC remain largely unclear. Recent …

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-
inhibitory molecules known as immune checkpoints expressed by the immune cells. In …

In this study, eight quinazolinone derivatives were designed and synthesized. Their
inhibitory activities on α-glucosidase were assessed in vitro. Two compounds: 2-(4 …

The adverse toxicities and stemness are two major factors that constrained the usage of
therapeutic strategies to target several cancer types. Previous studies explored the efficacy …

Cardiac diseases have a high morbidity and mortality and affect the global population.
Based on recent accumulating evidence, Forkhead box O (FOXOs) play important roles in …

Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers,
named as (S)-and (R)-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β-d-glucopyranosyl …

Objective Interstitial lung disease (ILD) is a progressive and irreversible lung disease with
very limited therapeutic options. Previous studies have found that chemokine ligands …

Forkhead box protein 3a (FOXO3a) is a transcription factor that regulates various
downstream targets upon its activation, leading to the upregulation of tumor suppressor and …

Gastric cancer is a common gastrointestinal malignancy worldwide, with a high mortality rate
and poor prognosis. Esomeprazole (ESO) has been shown to have anticancer activity by …