Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Clinical pharmacogenetics and potential application in personalized medicine
SF Zhou, Y Ming Di, E Chan, YM Du… - Current drug …, 2008 - ingentaconnect.com
The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …
Mechanisms of multidrug resistance in cancer
JP Gillet, MM Gottesman - Multi-drug resistance in cancer, 2010 - Springer
The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
CYP2C9 Genotype‐guided Warfarin Prescribing Enhances the Efficacy and Safety of Anticoagulation: A Prospective Randomized Controlled Study
Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …
Predictive Value of Known and Novel Alleles of CYP2B6 for Efavirenz Plasma Concentrations in HIV‐infected Individuals
M Rotger, H Tegude, S Colombo… - Clinical …, 2007 - Wiley Online Library
To assess the association of CYP2B6 allelic diversity with efavirenz (EFV) pharmacokinetics,
we performed extensive genoty** of 15 relevant single nucleotide polymorphism in 169 …
we performed extensive genoty** of 15 relevant single nucleotide polymorphism in 169 …
Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy …
K Klein, T Lang, T Saussele… - Pharmacogenetics …, 2005 - journals.lww.com
The present study investigated CYP2B6 genetic variability by sequencing genomic DNA
samples of African-American, Ghanaian, Taiwanese, Japanese and Korean subjects …
samples of African-American, Ghanaian, Taiwanese, Japanese and Korean subjects …
Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro
Objectives: To determine the influence of cytochrome P450 2B6 (CYP2B6) genotype on the
rate of oxidative efavirenz metabolism in human liver microsomes. Materials & methods …
rate of oxidative efavirenz metabolism in human liver microsomes. Materials & methods …
Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6* 6 and* 26
H Gatanaga, T Hayashida, K Tsuchiya… - Clinical infectious …, 2007 - academic.oup.com
Background. Efavirenz (EFV) is metabolized primarily by cytochrome P450 2B6 (CYP2B6),
and high plasma concentrations of the drug are associated with a G→ T polymorphism at …
and high plasma concentrations of the drug are associated with a G→ T polymorphism at …
Adherence-resistance relationships to combination HIV antiretroviral therapy
Early views on the relationship between adherence and resistance postulated a bell-shaped
relationship that balanced selective drug pressure and improved viral suppression along a …
relationship that balanced selective drug pressure and improved viral suppression along a …
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants
ER Holzinger, B Grady, MD Ritchie… - Pharmacogenetics …, 2012 - journals.lww.com
Objectives Prior candidate gene studies have associated CYP2B6 516G→ T [rs3745274]
and 983T→ C [rs28399499] with increased plasma efavirenz exposure. We sought to …
and 983T→ C [rs28399499] with increased plasma efavirenz exposure. We sought to …