A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment
Aims As an analgesic that acts upon the central nervous system (CNS), tramadol has gained
popularity in treating moderate to severe pain. Recently, it has been increasingly reported as …
popularity in treating moderate to severe pain. Recently, it has been increasingly reported as …
Incidence and general hospital costs of self-harm across England: estimates based on the multicentre study of self-harm
AimsThe aim of this study was to estimate incidence of self-harm presentations to hospitals
and their associated hospital costs across England. MethodsWe used individual patient data …
and their associated hospital costs across England. MethodsWe used individual patient data …
[HTML][HTML] Misappropriation of the 1986 WHO analgesic ladder: the pitfalls of labelling opioids as weak or strong
Opioids have a vital role in alleviating pain from cancer and surgery. Despite good
intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from …
intentions, it is now recognised that the original WHO Cancer Pain Relief guidance from …
Suicide‐related over‐the‐counter analgesic exposures reported to United States poison control centers, 2000‐2018
AG Hopkins, HA Spiller, S Kistamgari… - … and drug safety, 2020 - Wiley Online Library
Purpose To investigate suicide‐related over‐the‐counter (OTC) analgesic medication
exposures among individuals≥ 6 years old reported to United States (US) poison control …
exposures among individuals≥ 6 years old reported to United States (US) poison control …
Repeated administration of clinically relevant doses of the prescription opioids tramadol and tapentadol causes lung, cardiac, and brain toxicity in wistar rats
Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …
prescribed due to the enhanced therapeutic profiles resulting from the synergistic …
Repeated administration of clinical doses of tramadol and tapentadol causes hepato-and nephrotoxic effects in Wistar rats
Tramadol and tapentadol are fully synthetic and extensively used analgesic opioids,
presenting enhanced therapeutic and safety profiles as compared with their peers. However …
presenting enhanced therapeutic and safety profiles as compared with their peers. However …
Drug overdose deaths during prison riots and mental states of prisoners: a case study
L Tomassini, G Giuli, E Bottoni, MC David… - Frontiers in …, 2024 - frontiersin.org
Prison riots, though often sensationalized in the media, have profound consequences, with a
significant death toll. Prison populations, historically plagued by psychiatric disorders …
significant death toll. Prison populations, historically plagued by psychiatric disorders …
[HTML][HTML] A retrospective analysis of therapeutic drug exposures in New Zealand National Poisons Centre data 2018–2020
Abstract Objective The New Zealand National Poisons Centre advises the general public
and health professionals on management of exposures to various substances. The …
and health professionals on management of exposures to various substances. The …
Rural community pharmacy approaches to lethal means management for suicide prevention
Introduction Medications are common means of suicide. Rural areas have high suicide
rates, greater proportions of older adults and veterans, and few providers. We assessed the …
rates, greater proportions of older adults and veterans, and few providers. We assessed the …
Estimates of paracetamol poisoning in Brazil: analysis of official records from 1990s to 2020
O Jhh, G Tf, S Mt - Frontiers in pharmacology, 2022 - frontiersin.org
Objective: To assess the cases of paracetamol poisoning in Brazil. Methods: Analysis of
official records of deaths between 1996 and 2019 from the Brazil Mortality Information …
official records of deaths between 1996 and 2019 from the Brazil Mortality Information …