Progress and challenges in the field of snakebite envenoming therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

M Benard-Valle, Y Wouters, A Ljungars… - Nature …, 2024 - nature.com
Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions
of similar and dissimilar antigens, making them versatile tools for the treatment of eg …

[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies

S Thumtecho, NJ Burlet, A Ljungars… - Journal of Venomous …, 2023 - SciELO Brasil
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies

L Riaño-Umbarila, T Olamendi-Portugal… - Toxins, 2024 - mdpi.com
Alternative recombinant sources of antivenoms have been successfully generated. The
application of such strategies requires the characterization of the venoms for the …

First transcriptome analysis of the venom glands of the scorpion Hottentotta zagrosensis (Scorpions: Buthidae) with focus on venom lipolysis activating peptides

F Salabi, H Jafari, M Mahdavinia… - Frontiers in …, 2024 - frontiersin.org
Introduction Scorpion venom is a rich source of biological active peptides and proteins.
Transcriptome analysis of the venom gland provides detailed insights about peptide and …

[HTML][HTML] Plug and play virus-like particles for the generation of anti-toxin antibodies

RJ Edge, AE Marriott, EL Stars, RN Patel… - Toxicon: X, 2024 - Elsevier
Snakebite is a major global health concern, for which antivenom remains the only approved
treatment to neutralise the harmful effects of the toxins. However, some medically important …

[HTML][HTML] V-ToCs (Venom Toxin Clustering): A tool for the investigation of sequence and structure similarities in snake venom toxins

K Kalogeropoulos, V Rosca, C O'Brien… - Toxicon, 2024 - Elsevier
Recently, there has been a major push toward the development of next-generation
treatments against snakebite envenoming. However, unlike current antivenoms that rely on …