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Progress and challenges in the field of snakebite envenoming therapeutics
JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
especially in the rural settings of tropical regions. Envenomings are still treated with animal …
In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model
Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions
of similar and dissimilar antigens, making them versatile tools for the treatment of eg …
of similar and dissimilar antigens, making them versatile tools for the treatment of eg …
[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies
L Riaño-Umbarila, T Olamendi-Portugal… - Toxins, 2024 - mdpi.com
Alternative recombinant sources of antivenoms have been successfully generated. The
application of such strategies requires the characterization of the venoms for the …
application of such strategies requires the characterization of the venoms for the …
First transcriptome analysis of the venom glands of the scorpion Hottentotta zagrosensis (Scorpions: Buthidae) with focus on venom lipolysis activating peptides
Introduction Scorpion venom is a rich source of biological active peptides and proteins.
Transcriptome analysis of the venom gland provides detailed insights about peptide and …
Transcriptome analysis of the venom gland provides detailed insights about peptide and …
[HTML][HTML] Plug and play virus-like particles for the generation of anti-toxin antibodies
RJ Edge, AE Marriott, EL Stars, RN Patel… - Toxicon: X, 2024 - Elsevier
Snakebite is a major global health concern, for which antivenom remains the only approved
treatment to neutralise the harmful effects of the toxins. However, some medically important …
treatment to neutralise the harmful effects of the toxins. However, some medically important …
[HTML][HTML] V-ToCs (Venom Toxin Clustering): A tool for the investigation of sequence and structure similarities in snake venom toxins
Recently, there has been a major push toward the development of next-generation
treatments against snakebite envenoming. However, unlike current antivenoms that rely on …
treatments against snakebite envenoming. However, unlike current antivenoms that rely on …