Functionalized nanomaterials capable of crossing the blood–brain barrier
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …
regulates exchanges between the central nervous system parenchyma and blood vessels …
The immune system in Parkinson's disease: what we know so far
Parkinson's disease is characterized neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …
Blood–brain barrier alterations and their impact on Parkinson's disease pathogenesis and therapy
K Lau, R Kotzur, F Richter - Translational neurodegeneration, 2024 - Springer
There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …
disease (PD), the second most common neurodegenerative disorder with rapidly rising …
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …
a significant global health challenge as well as a high socioeconomic burden. With aging …
Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
[HTML][HTML] Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases
P Głowacka, K Oszajca, A Pudlarz, J Szemraj… - Nutrients, 2024 - mdpi.com
Aging is the most prominent risk factor for neurodegeneration occurrence. The most
common neurodegenerative diseases (NDs), Alzheimer's (AD) and Parkinson's (PD) …
common neurodegenerative diseases (NDs), Alzheimer's (AD) and Parkinson's (PD) …
Glial polarization in neurological diseases: molecular mechanisms and therapeutic opportunities
Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
[HTML][HTML] Immune responses to central nervous system directed adeno-associated virus gene therapy: Does direct CNS delivery make a difference?
AL Harkins, PP Ambegaokar, AM Keeler - Neurotherapeutics, 2024 - Elsevier
Adeno-associated virus (AAV) mediated gene therapy is a leading gene delivery platform
with potential to transform the landscape of treatment for neurological disorders. While AAV …
with potential to transform the landscape of treatment for neurological disorders. While AAV …
Astrocytes: The Stars in Neurodegeneration?
Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …
Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …
caused by the interaction of genetic, environmental, and familial factors. These diseases …