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Multiplexed electrochemical assays for clinical applications
Rapid, accurate diagnoses are central to future efficient healthcare to identify diseases at
early stages, avoid unnecessary treatment, and improve outcomes. Electrochemical …
early stages, avoid unnecessary treatment, and improve outcomes. Electrochemical …
Synthetic antigen-conjugated dna systems for antibody detection and characterization
Antibodies are among the most relevant biomolecular targets for diagnostic and clinical
applications. In this Perspective, we provide a critical overview of recent research efforts …
applications. In this Perspective, we provide a critical overview of recent research efforts …
Electrochemical cell‐free biosensors for antibody detection
We report here the development of an electrochemical cell‐free biosensor for antibody
detection directly in complex sample matrices with high sensitivity and specificity that is …
detection directly in complex sample matrices with high sensitivity and specificity that is …
PAM‐Engineered Toehold Switches as Input‐Responsive Activators of CRISPR‐Cas12a for Sensing Applications
The RNA‐programmed CRISPR effector protein Cas12a has emerged as a powerful tool for
gene editing and molecular diagnostics. However, additional bio‐engineering strategies are …
gene editing and molecular diagnostics. However, additional bio‐engineering strategies are …
Programmable cell-free transcriptional switches for antibody detection
We report here the development of a cell-free in vitro transcription system for the detection of
specific target antibodies. The approach is based on the use of programmable antigen …
specific target antibodies. The approach is based on the use of programmable antigen …
Amplification-free ratiometric electrochemical aptasensor for point-of-care detection of therapeutic monoclonal antibodies
J Wan, Y Liang, Q Hu, Z Liang, W Feng, Y Tian… - Analytical …, 2023 - ACS Publications
The rapid quantification of therapeutic monoclonal antibodies (mAbs) is of great significance
to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized …
to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized …
Enzyme‐Linked DNA Displacement (ELIDIS) Assay for Ultrasensitive Electrochemical Detection of Antibodies
Here we report the development of a method for the electrochemical ultrasensitive detection
of antibodies that couples the programmability and versatility of DNA‐based systems with …
of antibodies that couples the programmability and versatility of DNA‐based systems with …
Single‐response duplexing of electrochemical label‐free biosensor from the same tag
JNY Costa, GJC Pimentel, JA Poker… - Advanced …, 2024 - Wiley Online Library
Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy.
Exploiting the vertical, meshed design of reproducible and low‐cost ultra‐dense …
Exploiting the vertical, meshed design of reproducible and low‐cost ultra‐dense …
Programing chemical communication: allostery vs multivalent mechanism
The emergence of life has relied on chemical communication and the ability to integrate
multiple chemical inputs into a specific output. Two mechanisms are typically employed by …
multiple chemical inputs into a specific output. Two mechanisms are typically employed by …
Wash-free, sandwich-type protein detection using direct electron transfer and catalytic signal amplification of multiple redox labels
Direct electron transfer (DET) between a redox label and an electrode has been used for
sensitive and selective sandwich-type detection without a wash step. However, applying …
sensitive and selective sandwich-type detection without a wash step. However, applying …