The cell biology of neurogenesis
M Götz, WB Huttner - Nature reviews Molecular cell biology, 2005 - nature.com
During the development of the mammalian central nervous system, neural stem cells and
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …
their derivative progenitor cells generate neurons by asymmetric and symmetric divisions …
Neural tissue engineering: strategies for repair and regeneration
▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …
[HTML][HTML] Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This
germinal region, which continually generates new neurons destined for the olfactory bulb, is …
germinal region, which continually generates new neurons destined for the olfactory bulb, is …
[HTML][HTML] Long-distance growth and connectivity of neural stem cells after severe spinal cord injury
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing
growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells …
growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells …
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …
individuals and society. The goal of research in this field is to find a means of restoring lost …
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
▪ Abstract Multipotent stem cells are clonal cells that self-renew as well as differentiate to
regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic …
regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic …
Stem cell therapy for human neurodegenerative disorders–how to make it work
Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult
Multipotent neural stem cells are present throughout the development of the central nervous
system (CNS), persist into adulthood in defined locations and can be derived from more …
system (CNS), persist into adulthood in defined locations and can be derived from more …
Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration
K Kadoya, P Lu, K Nguyen, C Lee-Kubli… - Nature medicine, 2016 - nature.com
The corticospinal tract (CST) is the most important motor system in humans, yet robust
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …
regeneration of this projection after spinal cord injury (SCI) has not been accomplished. In …
Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells
X Qian, Q Shen, SK Goderie, W He, A Capela… - Neuron, 2000 - cell.com
Multipotent stem cells that generate both neurons and glia are widespread components of
the early neuroepithelium. During CNS development, neurogenesis largely precedes …
the early neuroepithelium. During CNS development, neurogenesis largely precedes …