Tumor-induced osteomalacia: a comprehensive review

S Minisola, S Fukumoto, W **a, A Corsi… - Endocrine …, 2023 - academic.oup.com
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

FGF23 and its role in X-linked hypophosphatemia-related morbidity

SS Beck-Nielsen, Z Mughal, D Haffner… - Orphanet Journal of …, 2019 - Springer
Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

Tumour-induced osteomalacia

S Minisola, M Peacock, S Fukumoto… - Nature reviews Disease …, 2017 - nature.com
Abstract Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a
rare paraneoplastic disorder caused by tumours that secrete fibroblast growth factor 23 …

Tumor-induced osteomalacia

P Florenzano, IR Hartley, M Jimenez, K Roszko… - Calcified Tissue …, 2021 - Springer
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumoral
production of fibroblast growth factor 23 (FGF23). The hallmark biochemical features include …

Tumor-induced osteomalacia: a systematic clinical review of 895 cases

A Bosman, A Palermo, J Vanderhulst… - Calcified tissue …, 2022 - Springer
Tumor-induced osteomalacia (TIO) is a rare and largely underdiagnosed paraneoplastic
condition. Previous reviews often reported incomplete data on clinical aspects, diagnosis or …

Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)

G Jacquillet, RJ Unwin - Pflügers Archiv-European Journal of Physiology, 2019 - Springer
Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

The PTH-vitamin d-FGF23 axis

JE Blau, MT Collins - Reviews in Endocrine and Metabolic Disorders, 2015 - Springer
Abstract Fibroblast growth factor 23 (FGF23) has emerged as an important regulator of
phosphate and vitamin D homeostasis. It is important to understand how FGF23 interacts …

Tumor‐induced osteomalacia: an important cause of adult‐onset hypophosphatemic osteomalacia in China: report of 39 cases and review of the literature

Y Jiang, W **a, X **ng, BC Silva, M Li… - Journal of Bone and …, 2012 - academic.oup.com
Tumor‐induced osteomalacia (TIO) is an acquired form of hypophosphatemia. Tumor
resection leads to cure. We investigated the clinical characteristics of TIO, diagnostic …

Interim analysis of a phase 2 open‐label trial assessing burosumab efficacy and safety in patients with tumor‐induced osteomalacia

Y Imanishi, N Ito, Y Rhee, Y Takeuchi… - Journal of Bone and …, 2020 - academic.oup.com
Patients with tumor‐induced osteomalacia (TIO), an acquired paraneoplastic condition
characterized by osteomalacia due to hypophosphatemia, exhibit a similar clinical picture to …

X-linked hypophosphatemia and FGF23-related hypophosphatemic diseases: prospect for new treatment

Y Kinoshita, S Fukumoto - Endocrine reviews, 2018 - academic.oup.com
Phosphate plays essential roles in many biological processes, and the serum phosphate
level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the …