Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential;
however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy …

The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary
cilia. The recently discovered role of primary cilia in nutrient sensing and signalling …

Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for
tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this …

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the
ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most …

Primary cilia are evolutionarily conserved cellular organelles that organize diverse
signalling pathways,. Defects in the formation or function of primary cilia are associated with …