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Nanomaterials for cancer therapy: current progress and perspectives
Cancer is a disease with complex pathological process. Current chemotherapy faces
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem …
A comprehensive review of small interfering RNAs (siRNAs): mechanism, therapeutic targets, and delivery strategies for cancer therapy
J Zhang, B Chen, C Gan, H Sun, J Zhang… - International journal of …, 2023 - Taylor & Francis
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …
strategy in the study and treatment of cancer. Short nucleotide sequences are synthesized …
[HTML][HTML] Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
While prime editing enables precise sequence changes in DNA, cellular determinants of
prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that …
prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that …
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma
Glioblastoma (GBM) is one of the most difficult cancers to effectively treat, in part because of
the lack of precision therapies and limited therapeutic access to intracranial tumor sites due …
the lack of precision therapies and limited therapeutic access to intracranial tumor sites due …
Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
Knocking down disease: a progress report on siRNA therapeutics
Small interfering RNAs (siRNAs), which downregulate gene expression guided by sequence
complementarity, can be used therapeutically to block the synthesis of disease-causing …
complementarity, can be used therapeutically to block the synthesis of disease-causing …
Delivery materials for siRNA therapeutics
RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene.
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
To achieve the clinical potential of RNAi, delivery materials are required to transport short …
Clinical experiences with systemically administered siRNA-based therapeutics in cancer
Small interfering RNA (siRNA)-based therapies are emerging as a promising new
anticancer approach, and a small number of Phase I clinical trials involving patients with …
anticancer approach, and a small number of Phase I clinical trials involving patients with …
[HTML][HTML] Clinical advances of siRNA-based nanotherapeutics for cancer treatment
Cancer is associated with single or multiple gene defects. Recently, much research has
focused on incorporating genetic materials as one of the means to treat various types of …
focused on incorporating genetic materials as one of the means to treat various types of …
Carbon nanocarriers deliver siRNA to intact plant cells for efficient gene knockdown
Posttranscriptional gene silencing (PTGS) is a powerful tool to understand and control plant
metabolic pathways, which is central to plant biotechnology. PTGS is commonly …
metabolic pathways, which is central to plant biotechnology. PTGS is commonly …