In chemical biology research, various fluorescent probes have been developed and used to
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …

Since its first demonstration, stimulated Raman scattering (SRS) microscopy has become a
powerful chemical imaging tool that shows promise in numerous biological and biomedical …

Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic
reprograming during therapeutic resistance development is under-studied. Here, through …

Fatty acids are an important source of energy and a key component of phospholipids in
membranes and organelles. Saturated fatty acids (SFAs) are converted into unsaturated fatty …

Metabolic reprogramming in a subpopulation of cancer cells is a hallmark of tumor
chemoresistance. However, single-cell metabolic profiling is difficult because of the lack of a …

Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms
of metabolic-related diseases. Current metabolic imaging studies suffer from limitations …

Single-cell multiparameter measurement has been increasingly recognized as a key
technology toward systematic understandings of complex molecular and cellular functions in …

Carboxylesterases (CEs) are a class of enzymes that catalyze the hydrolysis of esters in a
variety of endogenous and exogenous molecules. CEs play an important role in drug …

Lipids play crucial roles in many biological processes. Map** spatial distributions and
examining the metabolic dynamics of different lipid subtypes in cells and tissues are critical …

One of the biggest challenges in microbiome research in environmental and medical
samples is to better understand functional properties of microbial community members at a …