Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions

M Thastrup, A Duguid, C Mirian, K Schmiegelow… - Leukemia, 2022 - nature.com
Delivery of effective anti-leukemic agents to the central nervous system (CNS) is considered
essential for cure of childhood acute lymphoblastic leukemia. Current CNS-directed therapy …

[HTML][HTML] Targeted Therapy of Central Nervous System Acute Lymphoblastic Leukemia with an Integrin α6-Targeted Self-Assembling Proapoptotic Nanopeptide

JC Ye, WQ Li, ML Chen, QK Shi, H Wang, XL Li, YH Li… - Engineering, 2024 - Elsevier
There is currently no effective targeted therapeutic strategy for the treatment of central
nervous system acute lymphoblastic leukemia (CNS-ALL). Integrin α6 is considered a …

Central Nervous System-Directed Therapy

N Gajic, J Stary, C Halsey - Acute Lymphoblastic Leukemia in Children …, 2024 - Springer
The introduction of therapy to eradicate leukaemic cells in the central nervous system (CNS)
represented a breakthrough in the treatment of childhood acute lymphoblastic leukaemia …

Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche

A Duguid, C Malouf, L Nitsche, NA Barrett, OP Smith… - bioRxiv, 2024 - biorxiv.org
Infant B-cell acute lymphoblastic leukaemia (B-ALL) is a rare, aggressive entity
characterised by KMT2A rearrangements and poor outcomes. One of the unique features of …

Cambios epigenéticos y nucleares inducidos por el microambiente 3D que controlan la diseminación de la leucemia linfoblástica aguda

R González-Novo Martín - 2024 - docta.ucm.es
La leucemia linfoblástica aguda (LLA) es un tipo de cáncer altamente metastásico en el que
células linfoides en estadios tempranos de diferenciación crecen descontroladamente e …