Chemometric approaches have been increasingly viewed as precious complements to high
performance liquid chromatographic practices, since a large number of variables can be …

Highlights•We discuss the optimization role in new analytical method development.•We
show in detail the application of experimental designs in analytical chemistry.•Desirability …

The use of biodegradable films for releasing antimicrobials into food packaging is an active
packaging type in the food industry. In this study, an antibacterial film was produced based …

A review about the application of response surface methodology (RSM) in the optimization
of analytical methods is presented. The theoretical principles of RSM and steps for its …

The present paper describes fundamentals, advantages and limitations of the Box-Behnken
design (BBD) for the optimization of analytical methods. It establishes also a comparison …

In this tutorial the main concepts and applications of experimental design in chemistry will be
explained. Unfortunately, nowadays experimental design is not as known and applied as it …

Supercritical fluid extraction (SFE), a sustainable green technology leads a wide range of
applications since the past decade. Like many other processes, SFE is sometime s criticized …

In this research, artificial neural networks (ANN) and response surface methodology (RSM)
were applied for modeling and optimization of carbon dioxide (CO2) absorption using KOH …

This paper describes fundamentals and applications of multivariate statistical techniques for
the optimization of chromatographic systems. The surface response methodologies: central …

The present work evaluates and optimizes CO2 absorption in a bubble column for the Pz-
H2O–CO2 system. We analyzed the impact of the different operating conditions on the …