Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Objective To synthesize the growing body of literature on the role of social determinants of
health (SDoH) in asthma and asthma disparities. Data Sources A pubmed. gov search was …

Guideline-based management of asthma focuses on disease severity and choosing the
appropriate medical therapy to control symptoms and reduce the risk of exacerbations …

The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …

Background In phase 2 trials, lebrikizumab, an anti-interleukin-13 monoclonal antibody,
reduced exacerbation rates and improved FEV 1 in patients with uncontrolled asthma …

Background Short-term targeted treatment can potentially prevent fall asthma exacerbations
while limiting therapy exposure. Objective We sought to compare (1) omalizumab with …

Background Mepolizumab has demonstrated favorable safety and efficacy profiles in
placebo-controlled trials of 12 months' duration or less; however, long-term data are lacking …

Background: The fractional exhaled nitric oxide (FeNO) test is a point-of-care test that is
used in the assessment of asthma. Objective: To provide evidence-based clinical guidance …

Rationale: Although cigarette smoking is the most important cause of chronic obstructive
pulmonary disease (COPD), a substantial proportion of COPD cases cannot be explained by …

Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …