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Wild mouse gut microbiota promotes host fitness and improves disease resistance
Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …
limited in modeling complex diseases of humans and other free-living mammals. Because …
R/qtl2: software for map** quantitative trait loci with high-dimensional data and multiparent populations
R/qtl2 is an interactive software environment for map** quantitative trait loci (QTL) in
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
experimental populations. The R/qtl2 software expands the scope of the widely-used R/qtl …
A platform for experimental precision medicine: The extended BXD mouse family
The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …
phenotypes, development, environments, and treatments. We address this challenge by …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney
Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein …
process. In order to better understand these changes, we measured mRNA and protein …
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …
pathogen's ability to adapt to the variable immune pressures exerted by the host …
Genetic determinants of gut microbiota composition and bile acid profiles in mice
The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …
large inter-individual variation. While host genetics is a known factor that influences gut …
The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
The spatial folding of chromosomes inside the nucleus has regulatory effects on gene
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …
Genetic quality: a complex issue for experimental study reproducibility
A Yoshiki, G Ballard, AV Perez - Transgenic research, 2022 - Springer
Laboratory animal research involving mice, requires consideration of many factors to be
controlled. Genetic quality is one factor that is often overlooked but is essential for the …
controlled. Genetic quality is one factor that is often overlooked but is essential for the …
Content and performance of the MiniMUGA genoty** array: a new tool to improve rigor and reproducibility in mouse research
The laboratory mouse is the most widely used animal model for biomedical research, due in
part to its well-annotated genome, wealth of genetic resources, and the ability to precisely …
part to its well-annotated genome, wealth of genetic resources, and the ability to precisely …