The physical interaction of proteins which lead to compiling them into large densely
connected networks is a noticeable subject to investigation. Protein interaction networks are …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

Along with microglia and monocyte-derived macrophages, macrophages in the perivascular
space, choroid plexus, and meninges are the principal effector cells in neuroinflammatory …

Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously
expressed. S1P-S1PR signaling has been well characterized in immune trafficking and …

Importance Metabolic syndrome (MetS) is thought to influence several autoimmune
diseases, including multiple sclerosis (MS). Anti-inflammatory effects of treatments used for …

The first decade of Genome Wide Association Studies (GWAS) has uncovered a wealth of
disease-associated variants. Two important derivations will be the translation of this …

We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our
understanding of the disease was largely descriptive and there were no approved therapies …

Immunotherapy that targets lymphoid cell checkpoints holds great promise for curing cancer.
However, many cancer patients do not respond to this form of therapy. In addition to …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS)
susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to …

Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …