Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ
involvement, fibrosis and vasculopathy. Treatment in SSc, including early diffuse cutaneous …

This account of the mechanisms of scleroderma highlights the genetic and molecular
changes that cause the vascular changes and fibrosis in the disease. The role of …

The term 'sclerosing diseases of the skin'comprises specific dermatological entities, which
have fibrotic changes of the skin in common. These diseases mostly manifest in different …

Abstract Objectives Systemic sclerosis (SSc) is a rare disease requiring multicentre
collaboration to reveal comprehensive details of disease-related causes for morbidity and …

Abstract Background Validity of European Scleroderma Study Group (EScSG) activity
indexes currently used to assess disease activity in systemic sclerosis (SSc) has been …

Systemic sclerosis and autoimmune myositis are both associated with decreased quality of
life and increased mortality. Their prognosis and management largely depend on the …

Overlap Syndromes (OSs) have been defined as entities satisfying classification criteria of at
least two connective tissue diseases (CTDs) occurring at the same or at different times in the …

Objectives: To measure the prevalence of, and factors associated with, left ventricular (LV)
dysfunction in systemic sclerosis (SSc). Methods: The EUSTAR database was first searched …

Introduction In the present study, we analysed in detail nuclear autoantibodies and their
associations in systemic sclerosis (SSc) patients included in the German Network for …

As the diagnosis of systemic sclerosis (SSc) is generally suggested by the presence of
Raynaud's phenomenon followed by typical skin thickening associated with the presence of …