Targeted alpha therapy is an advancing experimental therapy that holds promise to deliver
high cytotoxicity to targeted cancer cells. Initially thought to be indicated for leukaemia and …

Antibody-based targeted therapies have been able to target cancers with enhanced
specificity and high efficacy. In this regard, identifying cancer markers (antigens) that are …

Control of micrometastatic pancreatic cancer remains a major objective in pancreatic cancer
treatment. The overexpression of MUC1 mucin plays an important role in cancer metastasis …

BACKGROUND.: MUC1 is associated with cellular transformation and tumorigenicity and is
considered as an important tumor-associated antigen (TAA) for cancer therapy. The …

MUC1 antigen is recognized as a high‐molecular‐weight glycoprotein that is unexpectedly
over‐expressed in human breast and other carcinomas. In contrast, C595 a monoclonal …

One of several effector mechanisms thought to contribute to Ab efficacy against cancer is
complement-dependent cytotoxicity (CDC). Serological analysis of a series of clinical trials …

The protein core of high mol. wt polymorphic epithelial mucin (PEM—approximately 400 kDa
glycoprotein) which is associated with breast carcinomas, consists of a repeating 20 amino …

Tumor MUC1 expression as well as levels of MUC1, MUC1 circulating immune complexes
(MUC1-CIC) and free antibodies against MUC1 (IgG and IgM-MUC1) were evaluated in 70 …

PURPOSE: More effective intravesical agents are required to limit the recurrence and
progression of superficial bladder cancer. This study assessed the ability of copper-67 …

Background HNSCC progression to adjacent tissue and nodes may be mediated by altered
glycoproteins and glycolipids such as MUC1 mucin. This report constitutes a detailed …