Recombinase polymerase amplification: Basics, applications and recent advances

IM Lobato, CK O'Sullivan - Trac Trends in analytical chemistry, 2018 - Elsevier
Recombinase polymerase amplification (RPA) is a highly sensitive and selective isothermal
amplification technique, operating at 37–42° C, with minimal sample preparation and …

A comprehensive summary of a decade development of the recombinase polymerase amplification

J Li, J Macdonald, F Von Stetten - Analyst, 2019 - pubs.rsc.org
Nucleic acid amplification has permeated every field in the life sciences since the
introduction of the classic polymerase chain reaction (PCR) method in 1983. Yet, despite its …

Recombinase polymerase amplification for diagnostic applications

RK Daher, G Stewart, M Boissinot… - Clinical …, 2016 - academic.oup.com
BACKGROUND First introduced in 2006, recombinase polymerase amplification (RPA) has
stirred great interest, as evidenced by 75 publications as of October 2015, with 56 of them …

Isothermal amplification of nucleic acids: The race for the next “gold standard”

BB Oliveira, B Veigas, PV Baptista - Frontiers in Sensors, 2021 - frontiersin.org
Nucleic acid amplification technologies (NAATs) have become fundamental tools in
molecular diagnostics, due to their ability to detect small amounts of target molecules. Since …

Onsite detection of plant viruses using isothermal amplification assays

AI Bhat, R Aman, M Mahfouz - Plant biotechnology journal, 2022 - Wiley Online Library
Plant diseases caused by viruses limit crop production and quality, resulting in significant
losses. However, options for managing viruses are limited; for example, as systemic obligate …

CRISPR-based rapid and ultra-sensitive diagnostic test for Mycobacterium tuberculosis

JW Ai, X Zhou, T Xu, M Yang, Y Chen… - Emerging microbes & …, 2019 - Taylor & Francis
Rapid and simple-to-use diagnostic methods for tuberculosis are urgently needed. Recent
development has unveiled the diagnostic power of the CRISPR system in the detection of …

Advanced DNA-based point-of-care diagnostic methods for plant diseases detection

HY Lau, JR Botella - Frontiers in plant science, 2017 - frontiersin.org
Diagnostic technologies for the detection of plant pathogens with point-of-care capability
and high multiplexing ability are an essential tool in the fight to reduce the large agricultural …

Critical insight into recombinase polymerase amplification technology

MA Munawar - Expert Review of Molecular Diagnostics, 2022 - Taylor & Francis
Introduction Recombinase polymerase amplification (RPA) is a promising and emerging
technology for rapidly amplifying target nucleic acid from minimally processed samples and …

Development and applications of portable biosensors

B Srinivasan, S Tung - Journal of laboratory automation, 2015 - journals.sagepub.com
The significance of microfluidics-based and microelectromechanical systems–based
biosensors has been widely acknowledged, and many reviews have explored their potential …

Influence of sequence mismatches on the specificity of recombinase polymerase amplification technology

RK Daher, G Stewart, M Boissinot, DK Boudreau… - Molecular and cellular …, 2015 - Elsevier
Recombinase polymerase amplification (RPA) technology relies on three major proteins,
recombinase proteins, single-strand binding proteins, and polymerases, to specifically …