Zika virus (ZIKV), a mosquito-borne positive-stranded RNA virus of the family Flaviviridae
(genus Flavivirus), is now causing an unprecedented large-scale outbreak in the Americas …

Small-molecule drugs are organic compounds affecting molecular pathways by targeting
important proteins. These compounds have a low molecular weight, making them penetrate …

The substitution of a single hydrogen atom in a protein by fluorine yields a site-specific
probe for sensitive detection by 19F nuclear magnetic resonance (NMR) spectroscopy …

Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The
protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing …

Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of
mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic …

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages
by host and viral proteases in order to produce the individual proteins that constitute an …

Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes, has
emerged as a major health concern. ZIKV infections can cause serious neurological …

Zika virus (ZIKV) became a public health emergency of global concern in 2015 due to its
rapid expansion from French Polynesia to Brazil, spreading quickly throughout the …

Highlights•Molecular structures and predicated models of flaviviral NS proteins.•Recent
advance in antiviral development targeting NS proteins.•Inhibitors targeting NS4B entering …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …