NRF2: KEA** tumors protected
R Pillai, M Hayashi, AM Zavitsanou… - Cancer Discovery, 2022 - AACR
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
Bilirubin as a metabolic hormone: the physiological relevance of low levels
JF Creeden, DM Gordon, DE Stec… - American Journal of …, 2021 - journals.physiology.org
Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …
suggests an entirely new function as a metabolic hormone that drives gene transcription by …
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
Clinical measurements can be viewed as useful intermediate phenotypes to promote
understanding of complex human diseases. To acquire comprehensive insights into the …
understanding of complex human diseases. To acquire comprehensive insights into the …
Bilirubin nanomedicine rescues intestinal barrier destruction and restores mucosal immunity in colitis
Inflammatory bowel disease (IBD) manifests as intestinal barrier destruction, mucosal
immunity dysregulation, and disrupted gut microbiome homeostasis. Conventional anti …
immunity dysregulation, and disrupted gut microbiome homeostasis. Conventional anti …
The diverse roles of heme oxygenase-1 in tumor progression
Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …
response to a variety of stimuli to degrade heme, which generates the biologically active …
The systemic-immune-inflammation index independently predicts survival and recurrence in resectable pancreatic cancer and its prognostic value depends on …
Objective: Our aim was to determine the prognostic significance of the systemic-immune-
inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific …
inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific …
Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases
SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020 - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …
Bilirubin nanoparticles as a nanomedicine for anti‐inflammation therapy
Despite the high potency of bilirubin as an endogenous anti‐inflammatory compound, its
clinical translation has been hampered because of its insolubility in water. Bilirubin‐based …
clinical translation has been hampered because of its insolubility in water. Bilirubin‐based …
A novel perspective on the biology of bilirubin in health and disease
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver …
Handling heme: The mechanisms underlying the movement of heme within and between cells
Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …