This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

A recent increase in the literature regarding the evidence base for clozapine has made it
increasingly difficult for clinicians to judge “best evidence” for clozapine use. As such, we …

Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …

Abstract Using Richardson and Davidson's model and the sciences of pharmacokinetics and
clinical pharmacopsychology, this article reviewed the:(1) poor life expectancy associated …

Objective Clozapine is the most effective medication for treatment‐refractory schizophrenia,
but it is associated with severe cardiac adverse events including myocarditis and …

REFLECTIONS ON THE COMPLEX HISTORY OF THE CONCEPT OF CLOZAPINE-INDUCED
INFLAMMATION DURING TITRATION Page 1 411 Psychiatria Danubina, 2022; Vol. 34, No. 3 …

Clozapine is an effective antipsychotic medication used for treatment‐resistant
schizophrenia. However, it is underutilized due to rigorous hematologic monitoring …

Introduction The incidence of clozapine-associated myocarditis varies by country. These
variations were explored in VigiBase, the World Health Organization's global database …

Purpose Although clozapine was Food and Drug Administration (FDA) approved more than
3 decades ago, major barriers and gaps in knowledge continue to prevent its effective and …

Clozapine is the only approved antipsychotic for treatment-resistant schizophrenia (TRS).
Although a large body of evidence supports its efficacy and favorable risk-benefit ratio in …