Vascular networks are formed and maintained through a multitude of angiogenic processes,
such as sprouting, anastomosis and pruning. Only recently has it become possible to study …

Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

The family of Rho GTPases are intracellular signal transducers that link cell surface signals
to multiple intracellular responses. They are best known for their role in regulating actin …

Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the
primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent …

Host-microbial symbioses are vital to health; nonetheless, little is known about the role
crosskingdom signaling plays in these relationships. In a process called quorum sensing …

JCI - Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid
leukemia Go to JCI Insight About Editors Consulting Editors For authors Publication ethics …

Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically
triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in …

Epithelial cells cultured within collagen and laminin gels proliferate to form hollow and
polarized spherical structures, recapitulating the formation of a rudimentary epithelial organ …

The establishment of an apical–basal axis of polarity is essential for the organization and
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …