[HTML][HTML] Muscle abnormalities worsen after post-exertional malaise in long COVID

B Appelman, BT Charlton, RP Goulding… - Nature …, 2024 - nature.com
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months
after infection. A distinctive symptom of patients with long COVID is post-exertional malaise …

Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities

A Pocivavsek, R Schwarcz, S Erhardt… - Pharmacological Reviews, 2024 - Elsevier
Both preclinical and clinical studies implicate functional impairments of several neuroactive
metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

[PDF][PDF] Treatment of 95 post-Covid patients with SSRIs

CP Rus, BEK de Vries, IEJ de Vries, I Nutma… - Scientific reports, 2023 - nature.com
Abstract After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms
indicate numerous affected organ systems. After a year, chronic fatigue, dysautonomia and …

[HTML][HTML] Immune mechanisms underpinning long COVID: collegium internationale allergologicum update 2024

E Untersmayr, C Venter, P Smith, J Rohrhofer… - … Archives of Allergy and …, 2024 - karger.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
result in a prolonged multisystem disorder termed long COVID, which may affect up to 10 …

Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies—An Interim Report

E Stein, C Heindrich, K Wittke, C Kedor, L Kim… - Journal of Clinical …, 2023 - mdpi.com
There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). SARS-CoV-2 has now become the …

Kynurenines, Neuronal Excitotoxicity, and Mitochondrial Oxidative Stress: Role of the Intestinal Flora

G Nagy-Grócz, E Spekker, L Vécsei - International Journal of Molecular …, 2024 - mdpi.com
The intestinal flora has been the focus of numerous investigations recently, with inquiries not
just into the gastrointestinal aspects but also the pathomechanism of other diseases such as …

Transfer of IgG from Long COVID patients induces symptomology in mice

HJ Chen, B Appelman, H Willemen, A Bos, J Prado… - BioRxiv, 2024 - biorxiv.org
SARS-CoV-2 infections worldwide led to a surge in cases of Long COVID, a post-infectious
syndrome. It has been hypothesized that autoantibodies play a crucial role in the …

Role of kynurenine and its derivatives in the neuroimmune system

M Fujikawa, M Ueda, K Maruyama - International Journal of Molecular …, 2024 - mdpi.com
In recent years, there has been a growing realization of intricate interactions between the
nervous and immune systems, characterized by shared humoral factors and receptors. This …