Non-viral vectors for gene-based therapy

H Yin, RL Kanasty, AA Eltoukhy, AJ Vegas… - Nature reviews …, 2014 - nature.com
Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications

AK Agrahari, P Bose, MK Jaiswal, S Rajkhowa… - Chemical …, 2021 - ACS Publications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Supramolecular cancer nanotheranostics

J Zhou, L Rao, G Yu, TR Cook, X Chen… - Chemical Society …, 2021 - pubs.rsc.org
Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

DNA functional materials assembled from branched DNA: design, synthesis, and applications

Y Dong, C Yao, Y Zhu, L Yang, D Luo… - Chemical Reviews, 2020 - ACS Publications
DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

E Pérez-Herrero, A Fernández-Medarde - European journal of …, 2015 - Elsevier
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Supramolecular coordination: self-assembly of finite two-and three-dimensional ensembles

R Chakrabarty, PS Mukherjee, PJ Stang - Chemical reviews, 2011 - ACS Publications
Fascination with supramolecular chemistry over the past few decades has led to the
synthesis of an ever-increasing number of elegant and intricate functional structures with …

Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives

X Chen, T Pradhan, F Wang, JS Kim, J Yoon - Chemical reviews, 2012 - ACS Publications
The recognition and sensing of biologically and environmentally important species has
emerged as a significant goal in the field of chemical sensors in recent years. 1Ā10 Several …

Design of polymeric nanoparticles for biomedical delivery applications

M Elsabahy, KL Wooley - Chemical Society Reviews, 2012 - pubs.rsc.org
Polymeric nanoparticles-based therapeutics show great promise in the treatment of a wide
range of diseases, due to the flexibility in which their structures can be modified, with …