There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …

Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …

Background Since the early 1980s, papillary thyroid cancer (PTC) incidence rates and the
prevalence of obesity, a risk factor for PTC, have increased substantially in the United …

Cisplatin is one of the most frequently used chemotherapeutic agents for treatment of a wide
range of cancer types. Nevertheless, the intrinsic or acquired resistance to cisplatin remains …

Lipids are the key component of all membranes composed of a variety of molecules that
transduce intracellular signaling and provide energy to the cells in the absence of nutrients …

Angelica sinensis polysaccharide (ASP) has hepatoprotective effects in liver injury models.
However, its role and mechanism in chronic liver fibrosis have not been fully elucidated. In …

Obesity is a chronic disease caused by the accumulation of excessive adipose tissue. This
disorder is characterized by chronic low‑grade inflammation, which promotes the release of …

Simple Summary STAT3, an oncogene, contributes to insensitivity of chemotherapy and
radiotherapy in tumor, reduces the clinical efficacy. Meanwhile, STAT3β, a STAT3 splicing …

In the past three decades, several recent studies have analyzed the alarming increase of
obesity worldwide, and it has been well established that the risk of many types of …

Obesity is a significant risk factor for cancer development. Within the tumor
microenvironment, adipocytes interact with cancer cells, immune cells, fibroblasts and …