It has been 15 years since the Leucine-rich repeat kinase 2 (LRRK2) gene was identified as
the most common genetic cause for Parkinson's disease (PD). The two most common …

Mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA) represent
two most common genetic causes of Parkinson's disease (PD). Both genes are important in …

In 2004, the identification of pathogenic variants in the LRRK2 gene across several families
with autosomal dominant late-onset Parkinson's disease (PD) revolutionized our …

Over the last decades, research on the pathobiology of neurodegenerative diseases has
greatly evolved, revealing potential targets and mechanisms linked to their pathogenesis …

Since 2005, The Michael J. Fox Foundation for Parkinson's Research (MJFF) has invested
significant funding and non-funding effort to accelerate research and drug development …

ROCO kinases form a family of proteins characterized by kinase activity in addition to the
presence of the so-called ROC (Ras of complex proteins)/COR (C-terminal of ROC) domains …

Parkinson's Disease triggering mutations are found within 23 genes or loci. Mutations of the
lrrk2 gene account for 5% of the cases among European and North American patients …

Disease modification remains a major unmet need in Parkinson's disease (PD) therapeutics.
Two decades ago, the discovery of familial mutations responsible for PD radically changed …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, affecting 3% of individuals of> 75 years of age. The disease is relentless and …

Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the most common cause of
familial Parkinson's disease (PD), with autosomal-dominant inheritance, and variants in this …