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Rheumatoid arthritis—common origins, divergent mechanisms
Rheumatoid Arthritis — Common Origins, Divergent Mechanisms | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
The pathogenesis of rheumatoid arthritis
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
[HTML][HTML] Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …
Mechanisms of joint destruction in rheumatoid arthritis—immune cell–fibroblast–bone interactions
N Komatsu, H Takayanagi - Nature Reviews Rheumatology, 2022 - nature.com
Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
Synovial inflammation in osteoarthritis progression
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
previous knowledge of target expression levels in the diseased tissue. Approximately 40 …
Cytokine networks in the pathogenesis of rheumatoid arthritis
N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …
inflammation causing progressive joint damage that can lead to lifelong disability. The …
Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis
MH Smith, VR Gao, PK Periyakoil, A Kochen… - Nature …, 2023 - nature.com
Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …
[HTML][HTML] Diversity and biology of cancer-associated fibroblasts
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …
compartment, despite the presence of non-neoplastic stromal components that substantially …
Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer
X Li, Z Sun, G Peng, Y **ao, J Guo, B Wu, X Li… - …, 2022 - pmc.ncbi.nlm.nih.gov
Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …