The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Abstract Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in
the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting …

Glucose-regulated protein (GRP78)/BiP, a major chaperone in the endoplasmic reticulum, is
recently discovered to be preferably expressed on the surface of stressed cancer cells …

Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the leading cause of viral
encephalitis in Southeast Asia with potential to become a global pathogen. Here, we identify …

Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD).
Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic …

The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal
neuron degeneration, and intraneuronal and intraneuritic proteinaceous inclusions named …

All eukaryotic cells are composed of the cytoskeleton, which plays crucial roles in
coordinating diverse cellular functions such as cell division, morphology, migration …

Background Different studies have shown the key role of endoplasmic reticulum (ER) stress
in autoimmune and chronic inflammatory disorders, as well as in neurodegenerative …