Palmitic acid: physiological role, metabolism and nutritional implications
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …
health effects, shadowing its multiple crucial physiological activities. PA is the most common …
SCD1, autophagy and cancer: implications for therapy
Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …
dysfunctional components and recycles them for other cellular functions. Over the years, a …
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …
protein modification, yet the metabolic consequence of mitochondrial protein …
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
AE Civitarese, S Carling, LK Heilbronn… - PLoS …, 2007 - journals.plos.org
Background Caloric restriction without malnutrition extends life span in a range of organisms
including insects and mammals and lowers free radical production by the mitochondria …
including insects and mammals and lowers free radical production by the mitochondria …
[HTML][HTML] Pathogenesis and prevention of hepatic steatosis
Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil
MJR Heerwagen, MR Miller… - American Journal of …, 2010 - journals.physiology.org
The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …
and developed countries worldwide. Even more alarming is the increasing prevalence of …
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
Insights into stearoyl-CoA desaturase-1 regulation of systemic metabolism
Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may
represent a therapeutic target to control obesity and the progression of related metabolic …
represent a therapeutic target to control obesity and the progression of related metabolic …
Gender differences in skeletal muscle substrate metabolism–molecular mechanisms and insulin sensitivity
AM Lundsgaard, B Kiens - Frontiers in endocrinology, 2014 - frontiersin.org
It has become increasingly apparent that substrate metabolism is subject to gender-specific
regulation, and the aim of this review is to outline the available evidence of molecular …
regulation, and the aim of this review is to outline the available evidence of molecular …
Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
MT Flowers, JM Ntambi - Current opinion in lipidology, 2008 - journals.lww.com
Recent studies in humans and animal models have highlighted that modulation of stearoyl-
coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly …
coenzyme A desaturase 1 activity by dietary intervention or genetic manipulation strongly …