Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Background Nicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in
every living cell, is involved in a myriad of metabolic processes associated with cellular …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Significance: Reducing equivalents (NAD (P) H and glutathione [GSH]) are essential for
maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive …

Chronic exposure of glucose rich environment creates several physiological and
pathophysiological changes. There are several pathways by which hyperglycemia …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Diabetes is a major public health disease that is globally approaching epidemic proportions.
One of the major causes of type 2 diabetes is either a defect in insulin secretion or insulin …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Metazoan organisms rely on conserved stress response pathways to alleviate adverse
conditions and preserve cellular integrity. Stress responses are particularly important in stem …

The Greek physician, Aretaios, coined the term “diabetes” in the 1st Century AD “Mellitus”
arose from the observation that the urine exhibits a sweetness due to its elevated glucose …