Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

Resistance (R) proteins recognize pathogen avirulence (Avr) proteins by direct or indirect
binding and are multidomain proteins generally carrying a nucleotide binding (NB) and a …

Here, we present APPRIS (http://appris. bioinfo. cnio. es), a database that houses
annotations of human splice isoforms. APPRIS has been designed to provide value to …

This review is an attempt to establish concepts of splicing and alternative splicing giving
proper relevance to introns, the key actors in this mechanism. It might also work as a guide …

If validated, diet‐derived foreign microRNA absorption and function in consuming
vertebrates would drastically alter our understanding of nutrition and ecology. RNA …

Human proteomic databases required for MS peptide identification are frequently updated
and carefully curated, yet are still incomplete because it has been challenging to acquire …

In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or
exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing …

Diverse proteins are found modified with glycosylphosphatidylinositol (GPI) at their carboxyl
terminus in eukaryotes, which allows them to associate with membrane lipid bilayers and …

Integrating large-scale functional genomic data has significantly accelerated our
understanding of gene functions. However, no algorithm has been developed to differentiate …