Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

The antigen-binding capacity of the paired variable domains of an antibody is well
established. The observation that the isolated heavy chains of anti-hapten antibodies retain …

Homology modelling has matured into an important technique in structural biology,
significantly contributing to narrowing the gap between known protein sequences and …

In principle, humans can produce an antibody response to any non-self-antigen molecule in
the appropriate context. This flexibility is achieved by the presence of a large repertoire of …

Structural antibody database (SAbDab; http://opig. stats. ox. ac. uk/webapps/sabdab) is an
online resource containing all the publicly available antibody structures annotated and …

A structural-bioinformatics-based computational methodology and framework have been
developed for the design of antibodies to targets of interest. RosettaAntibodyDesign (RAbD) …

A comparative analysis of the main-chain conformation of the L1, L2, L3, H1 and H2
hypervariable regions in 17 immunoglobulin structures that have been accurately …

By analyzing the human antibody repertoire in terms of structure, amino acid sequence
diversity and germline usage, we found that seven VH and seven VL (four Vκ and three Vλ) …

Clefts on protein surfaces are avoided by antigen-combining sites of conventional
antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that seem to be …

Monoclonal antibodies are playing an increasing role in both human and animal health.
Different strategies of protein and chemical engineering, including humanization techniques …