G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering
intracellular signaling through coupling with G proteins and arrestins. Recent breakthroughs …

The mammalian visual system encodes information over a remarkable breadth of
spatiotemporal scales and light intensities. This performance originates with its complement …

G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction
with arrestins, whose binding promotes receptor internalization and signaling through G …

The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

Following exposure of our eye to very intense illumination, we experience a greatly elevated
visual threshold, that takes tens of minutes to return completely to normal. The slowness of …

Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous
system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose …

The 4 mammalian arrestins serve as almost universal regulators of the largest known family
of signaling proteins, G-protein-coupled receptors (GPCRs). Arrestins terminate receptor …

The brain's capacity to analyse and interpret information is limited ultimately by the input it
receives. This sets a premium on information capacity of sensory receptors, which can be …

Phototransduction is the process by which light triggers an electrical signal in a
photoreceptor cell. Image-forming vision in vertebrates is mediated by two types of …

Background: Arrestins are responsible for the desensitization of many sequence-divergent G
protein-coupled receptors. They compete with G proteins for binding to activated …