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Acquired resistance to immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have rapidly altered the treatment landscape for multiple
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
Cancer evolution: Darwin and beyond
Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors
K Ford, CJ Hanley, M Mellone, C Szyndralewiez… - Cancer …, 2020 - aacrjournals.org
Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy
is key to develo** new treatment strategies. Cancer-associated fibroblasts (CAF) have …
is key to develo** new treatment strategies. Cancer-associated fibroblasts (CAF) have …
[HTML][HTML] Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient
We present an exceptional case of a patient with high-grade serous ovarian cancer, treated
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …
Three-year survival, correlates and salvage therapies in patients receiving first-line pembrolizumab for advanced Merkel cell carcinoma
Background Merkel cell carcinoma (MCC) is an aggressive skin cancer associated with poor
survival. Programmed cell death-1 (PD-1) pathway inhibitors have shown high rates of …
survival. Programmed cell death-1 (PD-1) pathway inhibitors have shown high rates of …
A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
D **ong, Y Wang, M You - Nature communications, 2020 - nature.com
Identifying factors underlying resistance to immune checkpoint therapy (ICT) is still
challenging. Most cancer patients do not respond to ICT and the availability of the predictive …
challenging. Most cancer patients do not respond to ICT and the availability of the predictive …
[HTML][HTML] Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer
Acquired resistance (AR) to programmed cell death protein 1/programmed death-ligand 1
[PD-(L) 1] blockade is frequent in non-small-cell lung cancer (NSCLC), occurring in a …
[PD-(L) 1] blockade is frequent in non-small-cell lung cancer (NSCLC), occurring in a …
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state
An open question in aggressive cancers such as melanoma is how malignant cells can shift
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …
Transcriptomic datasets of cancer patients treated with immune-checkpoint inhibitors: a systematic review
The availability of immune-checkpoint inhibitors (ICI) in the last decade has resulted in a
paradigm shift in certain areas of oncology. Patients can be treated either by a monotherapy …
paradigm shift in certain areas of oncology. Patients can be treated either by a monotherapy …