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Endothelial-specific cre mouse models: is your cre credibile?
S Payne, S De Val, A Neal - Arteriosclerosis, thrombosis, and …, 2018 - ahajournals.org
The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …
Cre mouse models to temporally and spatially manipulate gene expression within the …
The developmental biology of genetic Notch disorders
Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …
Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource
CS Heffner, C Herbert Pratt, RP Babiuk… - Nature …, 2012 - nature.com
Full realization of the value of the loxP-flanked alleles generated by the International
Knockout Mouse Consortium will require a large set of well-characterized cre-driver lines …
Knockout Mouse Consortium will require a large set of well-characterized cre-driver lines …
Murine coagulation factor VIII is synthesized in endothelial cells
The primary cellular source of factor VIII (FVIII) biosynthesis is controversial, with
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …
contradictory evidence supporting an endothelial or hepatocyte origin. LMAN1 is a cargo …
The in vivo endothelial cell translatome is highly heterogeneous across vascular beds
Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis …
interspersed anatomic distribution, comprehensive characterization of the molecular basis …
A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII
SA Fahs, MT Hille, Q Shi, H Weiler… - Blood, The Journal of …, 2014 - ashpublications.org
The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many
coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been …
coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been …
Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies
In recent years, technical developments in mouse genetics and imaging equipment have
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …
substantially advanced our understanding of hematopoietic stem cells (HSCs) and their …
[HTML][HTML] Pericytes are heterogeneous in their origin within the same tissue
Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well
known that pericytes from different organs may have distinct embryonic sources. Yamazaki …
known that pericytes from different organs may have distinct embryonic sources. Yamazaki …
Endothelial α5 and αv integrins cooperate in remodeling of the vasculature during development
A van der Flier, K Badu-Nkansah… - …, 2010 - journals.biologists.com
Integrin cell adhesion receptors and fibronectin, one of their extracellular matrix ligands,
have been demonstrated to be important for angiogenesis using functional perturbation …
have been demonstrated to be important for angiogenesis using functional perturbation …
FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis
Atherosclerotic cardiovascular disease is the leading cause of death in insulin-resistant
(type 2) diabetes. Vascular endothelial dysfunction paves the way for atherosclerosis …
(type 2) diabetes. Vascular endothelial dysfunction paves the way for atherosclerosis …