Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Nanoparticles (NPs) are highly potent tools for the diagnosis of diseases and specific
delivery of therapeutic agents. Their development and application are scientifically and …

Abnormal aggregation of proteins into filamentous aggregates commonly associates with
many diseases, such as Alzheimer's disease, Parkinson's disease and type-2 diabetes …

The development of biocompatible nanomaterials has become a new frontier in the
detection, treatment and prevention of human amyloid diseases. Here we demonstrated the …

The coexistence of amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) in the brain
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …

Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate
in Type 2 diabetes (T2D) and Alzheimer's disease (AD) brains and evidence suggests that …

Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …