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Investigations on the interface of nucleic acid aptamers and binding targets
Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …
have attracted substantial scientific interest due to their ability to specifically bind to target …
Methods and applications of in silico aptamer design and modeling
Aptamers are nucleic acid analogues of antibodies with high affinity to different targets, such
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
as cells, viruses, proteins, inorganic materials, and coenzymes. Empirical approaches allow …
Design and prediction of aptamers assisted by in silico methods
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
Artificial intelligence in aptamer–target binding prediction
Aptamers are short single-stranded DNA, RNA, or synthetic Xeno nucleic acids (XNA)
molecules that can interact with corresponding targets with high affinity. Owing to their …
molecules that can interact with corresponding targets with high affinity. Owing to their …
Synthetic riboswitches: from plug and pray toward plug and play
M Etzel, M Mörl - Biochemistry, 2017 - ACS Publications
In synthetic biology, metabolic engineering, and gene therapy, there is a strong demand for
orthogonal or externally controlled regulation of gene expression. Here, RNA-based …
orthogonal or externally controlled regulation of gene expression. Here, RNA-based …
Screening of a High-Affinity Aptamer for Aflatoxin M1 and Development of Its Colorimetric Aptasensor
Aflatoxin M1 (AFM1), a secondary metabolite of Aspergillus spp., is highly toxic and widely
present in food matrices. Therefore, the detection of AFM1 is of great importance for the …
present in food matrices. Therefore, the detection of AFM1 is of great importance for the …
A review: Construction of aptamer screening methods based on improving the screening rate of key steps
Aptamers, as recognition molecules, play an important role in the field of detection and
control. Screening is the key procedure to obtain aptamers. Improving the aptamer …
control. Screening is the key procedure to obtain aptamers. Improving the aptamer …
Opportunities in the design and application of RNA for gene expression control
The past decade of synthetic biology research has witnessed numerous advances in the
development of tools and frameworks for the design and characterization of biological …
development of tools and frameworks for the design and characterization of biological …
Inspirations of biomimetic affinity ligands: a review
Affinity chromatography is a well-known method dependent on molecular recognition and is
used to purify biomolecules by mimicking the specific interactions between the biomolecules …
used to purify biomolecules by mimicking the specific interactions between the biomolecules …
Structure‐and interaction‐based design of anti‐SARS‐CoV‐2 aptamers
Aptamer selection against novel infections is a complicated and time‐consuming approach.
Synergy can be achieved by using computational methods together with experimental …
Synergy can be achieved by using computational methods together with experimental …