Metabolic reprogramming and epigenetic modifications on the path to cancer

L Sun, H Zhang, P Gao - Protein & cell, 2022‏ - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The role of polyphenols in overcoming cancer drug resistance: A comprehensive review

P Maleki Dana, F Sadoughi, Z Asemi… - Cellular & Molecular …, 2022‏ - Springer
Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

Curcumin as an alternative epigenetic modulator: mechanism of action and potential effects

F Hassan, MS Rehman, MS Khan, MA Ali… - Frontiers in …, 2019‏ - frontiersin.org
Curcumin (a polyphenolic compound in turmeric) is famous for its potent anti-inflammatory,
anti-oxidant, and anti-cancer properties, and has a great potential to act as an epigenetic …

[HTML][HTML] Polyphenols as potent epigenetics agents for cancer

P Rajendran, SA Abdelsalam, K Renu… - International journal of …, 2022‏ - mdpi.com
Human diseases such as cancer can be caused by aberrant epigenetic regulation.
Polyphenols play a major role in mammalian epigenome regulation through mechanisms …

[HTML][HTML] Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy

I Arora, M Sharma, TO Tollefsbol - International journal of molecular …, 2019‏ - mdpi.com
Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …

Pharmacological mechanisms and clinical applications of curcumin: update

M Hao, Y Chu, J Lei, Z Yao, P Wang, Z Chen… - Aging and …, 2023‏ - pmc.ncbi.nlm.nih.gov
Curcumin, a well-known hydrophobic polyphenol extracted from the rhizomes of turmeric
(Curcuma longa L.), has attracted great interest in the last ten years due to its multiple …

The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022‏ - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Molecular targets of natural compounds with anti-cancer properties

M Kubczak, A Szustka, M Rogalińska - International Journal of Molecular …, 2021‏ - mdpi.com
Cancer is the second leading cause of death in humans. Despite rapid developments in
diagnostic methods and therapies, metastasis and resistance to administrated drugs are the …

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

JA McCubrey, K Lertpiriyapong… - Aging (Albany …, 2017‏ - pmc.ncbi.nlm.nih.gov
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and
other health-enhancing effects. A key target of the effects of natural products may be the …

Curcumin as a MicroRNA regulator in cancer: a review

AA Momtazi, F Shahabipour, S Khatibi… - Reviews of Physiology …, 2016‏ - Springer
Curcumin is a natural dietary polyphenol for which anti-tumor effects have been
documented. Anti-inflammatory and antioxidant properties of curcumin, along with its …