Abstract Changes in gene copy number are among the most frequent mutational events in
all genomes and were among the mutations for which a physical basis was first known. Yet …

During oncogenesis, cells acquire multiple genetic alterations that confer essential tumor-
specific traits, including immortalization, escape from antimitogenic signaling …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive …

The purpose of this study was to determine the deep sequencing and analytic conditions
needed to detect fetal subchromosome abnormalities across the genome from a maternal …

Tumor genomes are generally thought to evolve through a gradual accumulation of
mutations, but the observation that extraordinarily complex rearrangements can arise …

Cucumber (Cucumis sativus L.), a widely cultivated crop, has originated from Eastern
Himalayas and secondary domestication regions includes highly divergent climate …

Genomic rearrangements can result in losses, amplifications, translocations and inversions
of DNA fragments thereby modifying genome architecture, and potentially having clinical …

Background It has recently emerged that common epithelial cancers such as breast cancers
have fusion genes like those in leukaemias. In a representative breast cancer cell line, ZR …

Genomic structural variants, including translocations, inversions, insertions, deletions, and
duplications, are challenging to be reliably detected by traditional genomic technologies. In …

High‐grade serous ovarian carcinoma (HGSOC) is characterized by genomic instability,
ubiquitous TP53 loss, and frequent development of platinum resistance. Loss of …