[HTML][HTML] The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome
Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic …
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic …
Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy
Introduction It is crucial to understand the factors that introduce variability before applying
metabolomics to clinical and biomarker research. Objectives We quantified technical and …
metabolomics to clinical and biomarker research. Objectives We quantified technical and …
[HTML][HTML] Advances in the diagnosis and treatment of MET-variant digestive tract tumors
C Zhang, HK Dong, JM Gao, QQ Zeng… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
The receptor tyrosine kinase encoded by the MET gene plays an important role in various
cellular processes such as growth, survival, migration and angiogenesis, and its abnormal …
cellular processes such as growth, survival, migration and angiogenesis, and its abnormal …
Copy neutral loss of heterozygosity (cnLOH) patterns in synchronous colorectal cancer
Copy neutral loss of heterozygosity (cnLOH) is a common event in several human
malignancies—positing this as a mechanism of carcinogenesis. However, the role of cnLOH …
malignancies—positing this as a mechanism of carcinogenesis. However, the role of cnLOH …
SNP array genomic analysis of matched pairs of brain and liver metastases in primary colorectal cancer
VP Brandt, H Holland, M Wallenborn… - Journal of Cancer …, 2023 - Springer
Purpose Brain metastasis formation is a rare and late event in colorectal cancer (CRC)
patients and associated with poor survival. In contrast to other metastatic sites, the …
patients and associated with poor survival. In contrast to other metastatic sites, the …
[HTML][HTML] Показатель копийности генов у больных колоректальным раком как маркер клинического исхода заболевания и ответа на терапию
АА Маслов, ЛХ Чалхахян, СА Малинин… - Южно-российский …, 2022 - cyberleninka.ru
Аномальная копийность генов-особый типом генетических полиморфизмов, является
отличительной чертой большинства солидных опухолей, включая колоректальный рак …
отличительной чертой большинства солидных опухолей, включая колоректальный рак …
[HTML][HTML] The non-random landscape of somatically-acquired uniparental disomy in cancer
Uniparental disomy (UPD) was first described in 1980 by Engel and was defined as the
occurrence of inheriting a pair of homologous chromosomes from the same parental origin …
occurrence of inheriting a pair of homologous chromosomes from the same parental origin …
Identification of genetic factors associated with myeloid neoplasms
G Galata - 2022 - eprints.soton.ac.uk
Myeloid neoplasms are clonal haematopoietic disorders characterised by the abnormal
proliferation of specific myeloid cell types. The first part of this thesis focuses on …
proliferation of specific myeloid cell types. The first part of this thesis focuses on …
Research progress on uniparental disomy in cancer
D Chen, M Qi - Zhejiang da xue xue bao. Yi xue ban= Journal of …, 2019 - europepmc.org
单亲二体 (UPD) 是指个体的同源染色体或其上的一部分均来自于双亲中一方的一种染色体缺陷,
能够造成基因印记障碍或基因纯合突变, 从而导致各类疾病, 包括癌症. UPD 的形成机制多样 …
能够造成基因印记障碍或基因纯合突变, 从而导致各类疾病, 包括癌症. UPD 的形成机制多样 …
[HTML][HTML] 单亲二体及其在癌症中的作用研究进展
C Dianyu, QI Ming - Journal of Zhejiang University (Medical …, 2019 - ncbi.nlm.nih.gov
单亲二体（ UPD） 是指个体的同源染色体或其上的一部分均来自于双亲中一方的一种染色体缺陷
， 能够造成基因印记障碍或基因纯合突变， 从而导致各类疾病， 包括癌症。 UPD …
， 能够造成基因印记障碍或基因纯合突变， 从而导致各类疾病， 包括癌症。 UPD …