Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue
The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …
active substances has stimulated the development of new strategies and technologies for …
Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological …
Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a
unique class of diversified frameworks displaying a broad spectrum of biological functions …
unique class of diversified frameworks displaying a broad spectrum of biological functions …
Triazole derivatives as inhibitors of Alzheimer's disease: current developments and structure-activity relationships
M Xu, Y Peng, L Zhu, S Wang, J Ji… - European journal of …, 2019 - Elsevier
Alzheimer's disease (AD) is a well known neurodegenerative disorder alarming millions of
people worldwide and the subsequent epidemiological statistics highlights the implication of …
people worldwide and the subsequent epidemiological statistics highlights the implication of …
Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …
prevalence rate and associated complications. In this context, the current research work …
New frontiers in the transition-metal-free synthesis of heterocycles from alkynoates: an overview and current status
Heterocycles are among the well-established classes of compounds, constituting a wide
range of organic molecules. These structural motifs not only have a dominant presence in a …
range of organic molecules. These structural motifs not only have a dominant presence in a …
Hybrid quinoline-thiosemicarbazone therapeutics as a new treatment opportunity for Alzheimer's disease‒synthesis, in vitro cholinesterase inhibitory potential and …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of dementia worldwide. The limited pharmacological approaches based on …
cause of dementia worldwide. The limited pharmacological approaches based on …
Design and synthesis of new bis (1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazines) and bis ((quinoxalin-2-yl) phenoxy) alkanes as anti-breast cancer agents through dual …
A number of new 1, ω-bis ((acetylphenoxy) acetamide) alkanes 5a–f were prepared then
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
their bromination using NBS furnished the novel bis (2-bromoacetyl) phenoxy) acetamides …
New Coumarin-Pyrazole hybrids: Synthesis, Docking studies and Biological evaluation as potential cholinesterase inhibitors
A new set of hybrid derivatives bearing pyrazole and coumarin scaffold 3a-f was synthesized
and confirmed by different spectroscopic techniques (1 H NMR, 13 C NMR, FT-IR) and mass …
and confirmed by different spectroscopic techniques (1 H NMR, 13 C NMR, FT-IR) and mass …
Triazolothiadiazoles and Triazolothiadiazines as New and Potent Urease Inhibitors: Insights from In Vitro Assay, Kinetics Data, and In Silico Assessment
Hyperactivity of the urease enzyme induces the pathogenesis of peptic ulcers and gastritis.
The identification of new urease inhibitors can reduce the activity of urease. Therefore, in the …
The identification of new urease inhibitors can reduce the activity of urease. Therefore, in the …
Biological evaluation and molecular docking of novel 1, 3, 4-thiadiazole-resorcinol conjugates as multifunctional cholinesterases inhibitors
A Skrzypek, J Matysiak, M Karpińska, K Czarnecka… - Bioorganic …, 2021 - Elsevier
Abstract Two series of novel 1, 3, 4-thiadiazole-resorcinol conjugates were efficiently
synthesized and evaluated as cholinesterases inhibitors. N-Butyl-and N-chlorophenyl-5 …
synthesized and evaluated as cholinesterases inhibitors. N-Butyl-and N-chlorophenyl-5 …