Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Simple Summary U2 small nuclear RNA auxiliary factor 1 (U2AF1) is one of the most
important RNA splicing genes involved in regulating the alternative splicing of pre-mRNA …

Myelodysplastic syndrome (MDS) is a heterogeneous, clonal hematological disorder
characterized by ineffective hematopoiesis, cytopenia, morphologic dysplasia, and …

Acute myeloid leukemia (AML) is a clonal disease caused by genetic abberations occurring
predominantly in the elderly. Next generation sequencing (NGS) analysis has led to a …

Epigenetic mechanisms are crucial for sustaining cell type–specific transcription programs.
Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of …

Myelodysplastic neoplasm (MDS) represents a heterogeneous group of myeloid disorders
that originate from the hematopoietic stem and progenitor cells that lead to the development …

Simple Summary Myelodysplastic neoplasms and acute myeloid leukemias are often
caused by gene mutations. Next generation sequencing (NGS) has become indispensable …

TP53 dysregulation plays a pivotal role in the molecular pathogenesis of myelodysplastic
syndromes (MDS), identifying a subgroup of patients with peculiar features. In this review we …

The natural history of patients with myelodysplastic syndrome (MDS) is dependent upon the
presence and magnitude of diverse genetic and molecular aberrations. The International …

We examined the influence of mutations and karyotype on conventional treatment response,
specifically hematological improvement in anemia, in primary myelodysplastic syndromes …