Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

Prostate-specific membrane antigen (PSMA) is an important cell surface target in prostate
cancer. There are limited data on the heterogeneity of PSMA tissue expression in metastatic …

Prostate cancer is frequently characterized as a multifocal disease with great intratumoral
heterogeneity as well as a high propensity to metastasize to bone. Consequently, modeling …

HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the
differentiation of the prostate gland. Several studies have suggested that HOXB13 …

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …

Neuroendocrine prostate carcinoma (NEPC) accounts for less than 1% of prostate
neoplasms and has extremely poorer prognosis than the typical androgen receptor pathway …

Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa)
that frequently emerges in castration-resistant prostate cancer (CRPC). NEPC is usually …

Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from
adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors …

N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …

The androgen receptor (AR) signaling pathway is critical for growth and differentiation of
prostate cancer cells. For that reason, androgen deprivation therapy with medical or surgical …