Sepsis is a global health challenge, with over 49 million cases annually. Recent medical
advancements have increased in-hospital survival rates to approximately 80%, but the …

Sepsis and trauma were the primary inciting events. With tremendous the advances in care
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …

Objective: To analyze serial biomarkers of the persistent inflammation, immunosuppression,
and catabolism syndrome (PICS) to gain insight into the pathobiology of chronic critical …

Introduction Persistent inflammation, immunosuppression, and catabolism syndrome (PICS)
has been proposed as an endotype of chronic critical illness (CCI). The aim of this …

Sepsis after trauma increases the risk of mortality rate for patients in intensive care unit
(ICUs). Currently, it is difficult to predict outcomes in individual patients with sepsis due to the …

Background Over the past decade, advances in sepsis identification and management have
resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new …

Background: Sepsis is a leading cause of death in patients with trauma, and the risk of
mortality increases significantly for each hour of delay in treatment. A hypermetabolic …

Sepsis survivors experience a persistent myopathy characterized by skeletal muscle
weakness, atrophy, and an inability to repair/regenerate damaged or dysfunctional …

Purpose Age is considered a vital factor in intensive care units (ICUs) because of its
association with physiological frailty, comorbidities, and immune system function. Previous …

Objective: To assess factors associated with long-term neuropsychiatric outcomes, including
biomarkers measured after discharge from the intensive care unit. Methods: A prospective …