Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

BACKGROUND Since it was established that the cognitive brain is formed mostly by an
interconnected network of neurons that communicate at contact sites termed synapses …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Emerging evidence indicates that liquid–liquid phase separation, the formation of a
condensed molecular assembly within another diluted aqueous solution, is a means for cells …

Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …

Spatial and temporal control over chemical and biological processes plays a key role in life,
where the whole is often much more than the sum of its parts. Quite trivially, the molecules of …

The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

The spatiotemporal organization of neurotransmitter receptors in postsynaptic membranes is
a fundamental determinant of synaptic transmission and information processing by the brain …