Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

Osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) are
regarded as being of great importance in the regulation of bone remodeling. In this study, rat …

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell
types and have been widely used in tissue engineering application. In tissue engineering, a …

Mechanical loading is the primary functional determinant of bone mass and architecture,
and osteocytes play a key role in translating mechanical signals into (re) modelling …

A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

Bone marrow adipose tissue (MAT) is distinct from white adipose tissue (WAT) or brown
adipose tissue (BAT) for its location, feature and function. As a largely ignored adipose …

The cell cytoskeleton interprets and responds to physical cues from the microenvironment.
Applying mechanical force to mesenchymal stem cells induces formation of a stiffer …

Depolymerization of the actin cytoskeleton induces nuclear trafficking of regulatory proteins
and global effects on gene transcription. We here show that in mesenchymal stem cells …