The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

The profound effects of the bisphosphonates on calcium metabolism were discovered over
30 years ago, and they are now well established as the major drugs used for the treatment of …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …

While most T cells use a CD3-associated α/β T cell receptor as antigen recognition structure,
a second population of T cells expresses the alternative γ/δ T cell receptor. γ/δ T cells are a …

Nitrogen-containing bisphosphonates (nBPs) are bone-specific agents that inhibit farnesyl
diphosphate synthase. nBPs' strong affinity for bone, and not for other tissues, makes them …