The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur
in the organization, composition, and mechanical properties of the extracellular matrix …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Heart valve disease is a serious and growing public health problem for which prosthetic
replacement is most commonly indicated. Current prosthetic devices are inadequate for …

Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …

Bioactive and biodegradable hydrogels that mimic the extracellular matrix and regulate
valve interstitial cells (VIC) behavior are of great interest as three-dimensional (3-D) model …

The development of advanced scaffolds that recapitulate the anisotropic mechanical
behavior and biological functions of the extracellular matrix in leaflets would be …

Photocrosslinking hydrogel technologies are attractive for the biofabrication of
cardiovascular soft tissues, but 3D printing success is dependent on multiple variables. In …

Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They
have a remarkable ability to withstand the demanding mechanical environment of the heart …

As the first section of a multi-part review series, this section provides an overview of the
ongoing research and development aimed at fabricating novel heart valve replacements …

The second edition of An Introduction to Biomaterials consists of 33 chapters that have been
conceived and organized as a practical educational road map to provide a fundamental …